1. least favorable   OBSTREPEROUS   OPTIMUM   INVETERATE   DERANGED   Hint Half-n-half Clue   2. yielding   IRRELEVANT   INTRANSIGENT   OPPORTUNIST   JEOPARDY   Half-n-half Clue   3. purify   OBTUSE   DASTARD   OSTENTATIOUS   DEFILE   Half-n-half Clue   4. shrewd   INTER   OBTUSE   JUDICIOUS   DASTARD   Half-n-half Clue   5. praise   GOURMET   INTERMITTENT   OVERWEENING   OPPROBRIUM   Half-n-half Clue   6. harmless   DELETERIOUS   DEPRAVITY   OPPORTUNE   OSTENTATIOUS   Half-n-half Clue   7. stimulated   INTRANSIGENT   JADED   INURED   DEFILE   Half-n-half Clue